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Dimitrios Askitis1, Eleni I Efremidou1, Michail A Karanikas1, Grigorios Tripsianis1,

Alexandra Giatromanolaki2, Alexandros Polychronidis1 & Nikolaos Lyratzopoulos1

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Ανακοινώθηκε στο 19 European Congress of Endocrinology. Lisbon, Portugal 20-
23 May 2017

Δημοσιευτηκε σαν E-Poster (EP1378) DOI: 10.1530/endoabs.49.EP1378

Abstract

Aim: Thyroid cancer comprises the most common endocrine malignancy and a

variety of studies have investigated the role of thyroid autoimmunity as an
independent risk factor for the manifestation of differentiated thyroid cancer in
otherwise benign thyroid disorders. Objective of the current retrospective study is the

assessment of any possible correlation between thyroid autoimmunity, in terms of
elevated thyroid autoantibodies, and incidental thyroid microcarcinoma (ITC) in non-

toxic nodular thyroid diseases, subjected to total thyroidectomy (TT).

Patients and methods: In First Surgical Department between 1 January 2005 and 01

March 2010 a total of 186 patients (146 females/40 males) underwent TT after
referral for benign non-toxic nodular thyroid diseases. Surgical specimens were
evaluated in University Pathology Department and the diagnosis of ITC was recorded.

Elevated thyroid autoantibody titers were assessed in patients without (group A) and
those with (group B) thyroid cancer. The results were also compared regarding

preoperative diagnosis.

Results: 32 patients (17.2%) were diagnosed with microcarcinoma (females/males:

2.2/1), while 154 patients (82.8%) were free of malignancy. 9/34 patients with solitary
thyroid nodule (STN) and 33/152 subjects with multinodular goiter (MNG) had

biochemical signs of thyroid autoimmunity. 9/32 (28.1%) cancer patients had
elevated thyroid autoantibodies preoperatively. The prevalence of thyroid

autoimmunity was higher (non-statistically significant) in the cancer-group compared
to the non-cancer cohort (28.1% vs 21.4% respectively; P=0.41). Furthermore, the
prevalence of thyroid microcarcinoma was also higher (non-statistically significant)

in the autoimmunity subgroup compared to the non-autoimmunity subgroup (21.4%
vs 16%; P=0.41). These differences were manifested solely in the MNG group.

Conclusions: Thyroid autoimmunity does not seem to feature an independent risk
factor associated with thyroid microcarcinoma in non-toxic nodular thyroid diseases.

However, a non-significant higher correlation is recognized in the subgroup of

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