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comes second in sequence (F=62.04) showing that nivolumab is the most drastic preparation

               at low particle sizes (1.89), two drugs share an intermediate particle diameter (pembrolizumab
               and ipilimumab). In total drugs demonstrate a decreasing droplet size:
               Ipilimumab>Pembrolizumab> Nivolumab.



           44. Karanikas M, Kofina K, Boz Ali F, Vamvakerou V, Effraemidou E, Lyratzopoulos N, Polychronidis
               A. Primary greater omental torsion as a cause of acute abdomen-a rare case report.  J Surg

               Case Rep. 2018 Aug 7;2018(8):rjy207.  doi: 10.1093/jscr/rjy207. eCollection 2018 Aug.
               PMID: 30094002 [PubMed]  -


                   Abstract: Greater omental torsion is a rare entity that can cause acute abdominal pain, may
               mimick other abdominal pathologies, and is difficult to be diagnosed preoperatively. We

               present a case of a male patient with greater omental torsion mimicking the symptoms of

               acute appendicitis. A 31-year-old male patient presented with right scrotal pain, initially treated
               by the urologists, however, 24 h later, he presented right lower quadrant pain, with
               characteristics of acute appendicitis. After finding in ischemic inflammatory mass on

               McBurney incision, an exploratory laparotomy was performed, revealing torsion of the greater
               omentum. Torsion of the greater omentum can be a cause of acute abdomen and could be

               misdiagnosed with acute appendicitis. Preoperative diagnosis is not easy and resection of the
               affected tissue is the preferred treatment of choice.


           45. Karanikas M, Michalopoulos N, Kofina K, Laskou S, Kteniadakis N.  Lymph node mapping helps

               in R0 resection for anaplastic thyroid carcinoma-report of a case with prolonged survival.  J
               Surg Case Rep. 2019 Jun 20;2019(6):rjz197.   doi: 10.1093/jscr/rjz197. eCollection 2019 Jun.

               PMID: 31240095 [PubMed]


                   Abstract: Anaplastic thyroid carcinoma is a rare tumor, consisting 1-2% of all thyroid
               malignancies and presenting a high mortality rate. Median survival for patients undergoing

               primary surgery is approximately 6.6 months. We present a case of a patient treated with R0
               resection, including total thyroidectomy and lymphadenectomy of levels III, IV, VI and VII after

               cervical lymph node mapping, oral 131I administration, and radiotherapy. Proper preoperative
               research, R0 resection and relatively early diagnosis, led to good prognosis, as the patient is

               currently totally disease-free, twelve months postoperatively.


           46. Sapalidis K, Kosmidis C, Giannakidis D, Fyntanidou V, Barmpas A, Zarogoulidis P, Katsaounis
               A, Koulouris C, Michalopoulos N, Amaniti A, Aidoni Z, Mogoanta S, Karanikas M, Oikonomou P,

               Romanidis K, Vagionas A, Goganau AM, Munteanu A, Surlin V, Kesisoglou I. Laparoscopic





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