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694,000 people die from CRC annually. As it is expected is more frequent in older patients

(patients older than 70 years old than in young patients (patients younger than 40 years old).
The incidence of CRC in young adults is rising the last years and this fact arises the question;
is this coincidence or is young adult CRC a real epidemy. In our current commentary we try and

elucidate based on current data whether disease on young individuals is a new entity.

35. Ilias Karapantzos, Chrysa Karapantzou, Paul Zarogoulidis, Michail Karanikas, Vasilis

Thomaidis, Charalampos Charalampidis. Neoadjuvant Chemotherapy Followed by
Radiotherapy for Laryngeal Cancer. Journal of Biomedicine 2016, Vol. 1, 2016; 1: 32-35. doi:
10.7150/jbm.16927

Abstract Early stage of diagnosis is crucial for laryngeal cancer since the organ and function

preservation is wanted from the treating physicians. Currently the optimal care of patients with

laryngeal cancer is truly multidisciplinary, with progressive advances in surgical, radiation, and
medical oncology. Moreover; molecular targeted therapies are on their way.

Take home message: The treatment of patients with laryngeal cancer with systemic therapy
represents an opportunity to positively impact functional outcomes with an anatomically and

functionally preserved larynx. Future challenges include identification of novel molecular
pathways that upregulate tumorigenesis and suppression of these.

36. Karapantzos I, Zarogoulidis P, Karanikas M, Thomaidis V, Charalampidis C, Karapantzou C.
Obstruction of the right stem bronchus due to ovarianlocal metastasis: a 5-year follow-up.
Ann Transl Med. 2016 Nov;4(22):445. doi: 10.21037/atm.2016.10.75. PMID: 27999779

[PubMed]

Abstract: Currently interventional bronchoscopy is used for debulking, desobstruction and
airway patency stabilization. The interventional techniques are being used for both benign and

malignant cases. There are two types of stents that are currently being used, silicon and self-
expandable metallic. The method of application and stent remains for the treating physician to

choose. In the current case we will present a case of metastatic disease from ovarian cancer
in the airway lumen and a long term follow-up.

37. Karanikas M, Esempidis A, Chasan ZT, Deftereou T, Antonopoulou M, Bozali F, Amarantidis K,

Man YG. Pancreatic Cancer from Molecular Pathways to Treatment Opinion. J Cancer. 2016
Jun 25;7(10):1328-39. doi: 10.7150/jca.15419. eCollection 2016. PMID: 27390608

[PubMed] [Scopus]

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