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cholecystectomy—types, surgical intervention and timing. Annals of Translational Medicine.

2016; 4(9): 163. doi: 10.2103 7/atm.2 016.05,07 PMID: 27275476 [PubMed] [Scopus]

Abstract: Bile duct lesions, including leaks and strictures, are immanent complications of
open or laparoscopic cholecystectomy (LC). Endoscopic procedures have gained increasing

potential as the treatment of choice in the management of postoperative bile duct injuries. Bile
duct injuiy (BDI) is a severe and potentially life-threatening complication of LC. Several series

have described a 0,5% to 0.6% incidence of BDI during LC. Early recognition and an adequate
multidisciplinary approach are the cornerstones for the optimal final outcome, Suboptimal

management of injuries often leads to more extensive damage to the biliary tree and its
vasculature. Early referral to a tertiary care center with experienced hepatobiliary surgeons and

skilled interventional radiologists would appear to be necessary to assure optimal results.

33. Ilias Karapantzos, Paul Zarogoulidis, Michail Karanikas, Vasilis Thomaidis, Charalampos
Charalampidis, Chrysa Karapantzou. Head and Neck Cancer Therapy from Bench to Bedside.

Oncomedicine 2016, Vol. 1, 2016; 1: 18-24. doi: 10.7150/oncm.16928

Abstract Nowadays treatment of laryngeal and hypopharyngel cancer is not defined only by
surgical resection. Multimodality treatment approach is considered the best approach for

patients. Currently treatment includes chemotherapy , radiotherapy , and surgery . The goal
with combination treatment approach is to preserve organ and function. In the past years
unfortunately we had to deal with mutilating and function destroying treatment. In the past 25

years, evidences from large randomized trials presented data that organ preservation studies

using sequential and concomitant radio-chemotherapy do not compromise survival when
compared with surgery followed by radiotherapy. The side effects from multimodality
treatment approach has to take into account and the final goal has to be not only organ

preservation but also function preservation. In the current review we focus on the most
common treatment options. We conclude that there is an urgent need to refine the definition of

a functional organ and to refine recommendations for evaluating treatment response.

34. Michail Karanikas, Agis Esebidis. Increasing incidence of colon cancer in patients <50 years
old: a new entity? Annals of Translational Medicine. 2016; 4(9): 164. doi:

10.21037/atm.2016.04.13 PMID: 27275477 [PubMed] [Scopus]

Abstract: Colorectal cancer (CRC) is the third most common cancer type in humans, the fourth
most common cause of death because of cancer, and the second most common cancer type in

terms of the number of individuals living with cancer 5 years after diagnosis worldwide, almost

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