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resection of giant adrenal malignant tumors, a case series and review of the literature. AME

Case Rep. 2020 Jan 20;4:7. doi: 10.21037/acr.2019.11.04. eCollection 2020. PMID: 32206753
[PubMed]

Abstract: Laparoscopic approach for suspected adrenal malignancies remains a controversial
issue and it gets more controversial, when managing giant adrenal malignant tumors. The aim

of this paper is to present five cases of patients with giant adrenal malignant tumors that

underwent laparoscopic transabdominal lateral adrenalectomy in our department between
2010 and 2017. Literature is also reviewed in order to investigate the feasibility of
laparoscopic resection in these cases.

47. Touzopoulos P, Arvanitidis K, Filidou E, Tilkeridis K, Karanikas M, Kolios G, Ververidis A. Is

serum gentamicin concentration modified with autologous cell-saved blood transfusion after

total knee arthroplasty using tranexamic acid? A randomised control trial. Orthop Traumatol
Surg Res. 2020 Dec 14:102794. doi: 10.1016/j.otsr.2020.102794. Online ahead of print.
PMID: 33333277 [PubMed] [Scopus]

Abstract: Background: Self-transfusion has been proven as an effective management of blood

loss after total knee arthroplasty (TKA). Considering that the high local concentration of
antibiotic from bone cement is delivered intravenously through the self-transfusion process,

systematic toxicity has never been evaluated. In addition, the effectiveness of self-transfusion
with the routine concomitant use of other modern blood-salvage strategies, like tranexamic

acid, should also be assessed. Therefore, we performed a randomised study to assess: 1) the
safety of self-transfusion in TKA by comparing the gentamicin concentrations resulting from

the use or not of autologous blood transfusion; 2) the efficacy of self-transfusion in TKA, with
the concomitant administration of tranexamic acid.Hypothesis: Self-transfusion in TKA

elevates the serum gentamicin concentration and the potential risk of
nephrotoxicity.Methods: The serum concentration of aminoglycosides was measured in two

groups of 20 patients each, after TKA, according to the use of self-transfusion. Hemoglobin,
renal function and calculated blood loss were compared at several points in time between

groups.Results: The only time where there was a statistically significant difference in serum
gentamicin, was at 48h postoperatively between groups [0.3 ug/mL±0.21, range: 0.15 to 0.72

vs. 0.14ug/mL±0.1, range: 0 to 0.35 (p=0.02)]. There were no significant differences in total
blood loss [1341mL±501, range: 830 to 2230 vs. 1263mL±459 range: 840 to 2480 (p=0.67)]
and need of allogeneic blood transfusion [3 units vs. 2 units] between groups.Conclusion: The

use of autologous blood transfusion was found to be safe, in terms of nephrotoxicity of

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