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aminoglycosides after TKA, but it seemed to be ineffective as a blood salvage strategy, when

used concomitantly with the administration of tranexamic acid.

48. Zarogoulidis P, Huang H, Yang M, Zhou J, Jiao Y, Wang Q, Petridis D, Sapalidis K, Sardeli C,
Konsta P, Koulouris C, Michalopoulos N, Giannakidis D, Barbetakis N, Katsaounis A,

Hohenforst-Schmidt W, Amaniti A, Petanidis S, Tsakiridis K, Courcoutsakis N, Goganau AM,
Vagionas A, Romanidis K, Oikonomou P, Karanikas M, Katsios IN, Kesisoglou I, Kosmidis C.

Pleurodesis and Immunotherapy in NSCLC; Medical Thoracoscopy or VATS? PI. J Cancer.
2020 Jan 14;11(6):1606-1613. doi: 10.7150/jca.40004. eCollection 2020.
PMID: 32047566 [PubMed] [Scopus]

Abstract: Introduction: Immunotherapy is a treatment option for non-small cell lung cancer

advanced disease. However; immunotherapy in several patients induces orogonitis and

effusion in different cavities. It is up to the treating physician to understand whether there is
effusion due to adverse effect or disease progression. Pleurodesis in both cases might be a
solution for recurrent pleura effusion. Patients and Methods: Three hundred and thirty seven

non-small cell lung cancer patients with adenocarcinoma and pleura effusion during first line
immunotherapy treatment underwent medical thoracoscopy or Video assisted thoracic surgery

(VATS) for pleurodesis with talk poudrage. Uniportal medical thoracoscopy was performed
under general with dual channel endotracheal tube in one hundred and eleven patients. Video

assisted thoracic surgery was performed in one hundred and eighty seven patients and
conversion from medical to VATS procedure was done to thirty nine patients. All patients had

stage IV disease with pleura involvement and were under first line pembrolizumab treatment
with 200mg (PD-L1 ≥ 50%). Results: The quantitative parameters of the study (expression, PY

and cycle) were converted to an ordinal scale to facilitate the performance of statistical
analysis. All parameters were examined as dependent against the parameter technique acting

as independent to detect potential relationships. The results of multi Y versus X relationship
revealed no statistically significant effect (p>0.05) of the three

49. Effraimidou E, Kofina K, Giatromanolaki A, Chatzipantelis P, Karanikas M, Lyratzopoulos N.

Primary ectopic Merkel cell carcinoma without skin involvement-report of a case with
prolonged survival. J Surg Case Rep. 2020 Oct 27;2020(10):rjaa390. doi:

10.1093/jscr/rjaa390. eCollection 2020 Oct. PMID: 33163153 [PubMed]

Abstract: Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis,
in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only

rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with

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